I’ve been putting in a bit of work recently trying to make it easier for other researchers at Fred Hutch to use Nextflow as a way to run their bioinformatics workflows, while also getting the benefits of cloud computing and Docker-based computational reproducibility.
You can see some slides describing some of that content here, including a description of the motivation for using workflow managers, as well as a more detailed walk-through of using Nextflow right here at Fred Hutch.